TF Archives

Australian study shows drug Ecstasy slows learning.

Author:
Thursday, January 24, 2002
CANBERRA, Dec 14, 2001 (Reuters) - Illicit pill poppers using the popular party drug Ecstasy suffer permanent learning problems linked to known long-term loss of memory caused by temporary brain damage, an Australian study has found.

Australian National University psychologist Jeff Ward said on Friday memory tests and brain scans performed on 30 subjects who had recently taken Ecstasy revealed they struggled to process and learn new information, affecting their memory functions.

The scans showed the worst damage on the brain's cortical neurons linked to memory function, which can be impaired on three levels -- entry into the brain, storage and retrieval.

"Users have no difficulty in retrieving memories once they are learned, the problem lies in learning new material," Ward told Reuters.

"It takes more exposure to new material for them to learn."

Results revealed that in Ecstasy users, the brain cells linked to the three stages of memory had a decreased density of receptors for the neurotransmitter serotonin, which transports messages between cells and is known to affect mood.

"Even organised professionals like lawyers complained they would miss appointments and forget important facts long after using the drug," Ward said.

Previous research has suggested that ecstasy causes a flood of serotonin in the brain, followed by a lull when the drug wears off and ultimately damage to the brain's memory function.

Sometimes known as MDMA or by its chemical name 3,4-methylenedioxymethamphetamine, Ecstasy can also cause dramatic changes in heart rate and blood pressure.

Ward also did brain scans on 30 former Ecstasy users who had abstained from the drug for at least two years, showing damage to the serotonin receptors in cortical neurons had repaired.

But ex-users continued to struggle to digest new information and did not perform as well on memory tests as 30 control subjects who had never used the drug.

"The impairment is definitely noticeable in contrast to non-Ecstasy users," Ward said.

The study, involving users aged up to 30 years, showed the longer Ecstasy was used and the higher the dosages, the worse the memory impairment, Ward said.

Animal studies have shown damage to cells connected to memory function last up to seven years after exposure to the drug.

Tags